Cholesterol specifically is in the realm of relative unknowns for medicine. Especially the way it is measured, it may or may not be a predictor of heart disease or other maladies. It is also unknown why some populations have a higher baseline cholesterol, and how that affects their longterm health.

Speaking as a person who has had very high cholesterol from childhood with very healthy eating habits and despite being a very active athlete with <5% bodyfat.